It's easily the top bar followed by how the profile is no longer spread on all sides of the page, but rather stacked in the middle. This website used to look alot "softer", the colours were actually a pleasure.
I definitely agree with you Reorxo. Your whole profile is squooshed. It's a terrible design and an awful use of space.
I hate the fact that my friends are shoved into a dark, tiny corner at the bottom of the page. That's one of the most important things to me. I want it up front and center.
Users should be able to customize their page layout and move boxes around. It's not difficult to program and many other web sites do it (Yahoo, for examples).
There are so many things I hate about last.fm since the evil takeover, but the biggest, by far, is the apathy. The bigwigs don't give a flying fuck about us. We can scream at them until we're blue in the face and they won't even glance at us. All this protesting, complaining, letter writing, none of it penetrates their thick skulls. Last.fm users are dropping like flies and they are still deaf to us.
This place gets crappier and crappier every day. All we can do is watch it die a slow, horrible death.
Thing I dislike the most about new Last.fm